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目的 探讨铝碳酸镁对胆汁反流性胃炎疗效及胃内 2 4小时胆汁的影响。方法 3 0例胆汁反流性胃炎 ,经胃内 2 4小时胆汁监测证实 ,并随机分为 3组。一组服用西沙必利 5mg ,3次 /d ;一组服用铝碳酸镁 1.0 g ,3次 /d ;一组同时服用西沙必利和铝碳酸镁。治疗 4周后观察腹痛、腹胀、呕吐胆汁等症状变化 ,并复查胃内 2 4小时胆汁监测。结果 治疗后 3组患者症状均明显减轻 (P <0 .0 1) ,有效率分别为 90 % ,10 0 %和 10 0 %。 2 4小时胃内胆汁反流总时间百分比由治疗前 ( 15 .7± 7.8) % ,( 17.0±16.3 ) %和 ( 16.9± 15 .6) %降至 ( 4 .9± 4 .5 ) % (P <0 .0 1) ,( 0 .8± 0 .9) % (P <0 .0 1)和 ( 1.2± 2 .3 ) % (P<0 .0 1)。结论 铝碳酸镁可结合胃内胆汁 ,有效缓解胆汁反流性胃炎症状 ,为治疗胆汁反流性胃炎的有效药物。
Objective To investigate the curative effect of magnesium aluminum carbonate on bile reflux gastritis and the effect of 24 hours bile in the stomach. Methods Twenty cases of bile reflux gastritis were confirmed by 24 hours bile monitoring in the stomach and were randomly divided into three groups. One group received cisapride 5mg, 3 times / d; one group took 1.0g of aluminum magnesium carbonate 3 times / d; one group took cisapride and aluminum magnesium carbonate at the same time. After 4 weeks of treatment, abdominal pain, abdominal distension, vomiting and other symptoms of bile were observed, and the stomach was inspected for 24 hours bile monitoring. Results After treatment, the symptoms of the three groups were significantly reduced (P <0.01), the effective rates were 90%, 100% and 100% respectively. The total time of gastric reflux during 4 hours was (15.7 ± 7.8)%, (17.0 ± 16.3)% and (16.9 ± 15.6)% to (4.9 ± 4.5)% (P <0.01), (0.8 ± 0.9)% (P <0.01) and (1.2 ± 2.3)% (P <0.01), respectively. Conclusion Aluminum magnesium carbonate can be combined with intragastric bile, effectively relieve the symptoms of bile reflux gastritis, and is an effective drug for the treatment of bile reflux gastritis.