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检测了肺癌、肝癌、乳腺癌、鼻咽癌、肠癌、胃癌等12种恶性肿瘤共142例患者红细胞超氧化物歧化酶（SOD）活力和血浆脂质过氧化物（LPO）含量，结果显示12种恶性肿瘤患者红细胞SOD活力明显低于良性肿瘤组（P＜0．05）及正常对照组（P＜0．01），LPO含量明显高于良性肿瘤组及正常对照组（P＜0．01），但值得注意的是41例晚期肿瘤患者SOD明显高于中期组（P＜O．05）而与正常组无显著差别（P＞0．05），LPO明显高于正常组（P＜0．05）与中期组无显著差别（P＞0．05），尤其是在3周以内死亡的6例晚期患者SOD活力明显高于肿瘤组平均水平（P＜O．05），提示患恶性肿瘤时体内SOD防御系统受到严重破坏，由氧自由基引发的脂质过氧化反应与临床肿瘤发展过程一致，肿瘤后期SOD急剧上升可作为判断预后的重要指标。
A total of 142 patients with lung cancer, liver cancer, breast cancer, nasopharyngeal cancer, colorectal cancer, and gastric cancer were examined for the activity of superoxide dismutase (SOD) and plasma lipid peroxide (LPO) content in 142 patients. The activity of red blood cell SOD in 12 malignant tumor patients was significantly lower than that in benign tumor group (P<0.05) and normal control group (P<0.01), and the LPO content was significantly higher than benign tumor group and normal control group (P<0. 01), but it is worth noting that 41 patients with advanced cancer had significantly higher SOD than those in the mid-term group (P<0.05) and no significant difference from the normal group (P>0.05), and the LPO was significantly higher than the normal group (P<0.01). 0.05) was not significantly different from the intermediate group (P>0.05), especially in the 6 patients with late death within 3 weeks. SOD activity was significantly higher than the average level of the tumor group (P <0.05), suggesting that the malignant The SOD defense system in the body is severely damaged in tumors, and the lipid peroxidation reaction initiated by oxygen free radicals is consistent with the development of clinical tumors. The rapid rise of SOD in the late stage of tumors can be used as an important indicator of prognosis.