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本文用甲基强的松龙冲击治疗无效的一组(32例)顽固性肾病综合症,采用大剂量环磷酰胺(CTX)冲击加激素疗法获得较满意的效果。现报告如下。 1 临床资料 1.1 病例情况:32例均符合原发性肾病综合症的诊断标准。肾功能均正常。男11例,女21例,年龄15～72岁,平均年龄28岁。其病理分型:微小病变型肾病2例,膜型肾病8例,膜增生型肾小球肾炎4例,系膜增生型肾炎6例,局灶节段性肾小球硬化2例。平均病程8+7.1月。其中激素抵抗型18例,激素依赖型5例,反复发作型7例,激素不
In this paper, methylprednisolone impact treatment ineffective group (32 cases) refractory nephrotic syndrome, high dose cyclophosphamide (CTX) shock plus hormone therapy to obtain more satisfactory results. The report is as follows. 1 clinical data 1.1 cases: 32 cases are in line with the primary nephrotic syndrome diagnostic criteria. Renal function are normal. Eleven men and 21 women, aged 15 to 72 years, mean age 28 years. The pathological type: 2 cases of minimal change nephropathy, membranous nephropathy in 8 cases, 4 cases of membranous proliferative glomerulonephritis, mesangial proliferative nephritis in 6 cases, focal segmental glomerulosclerosis in 2 cases. The average duration of 8 +7.1 months. Of which 18 cases of hormone resistance, hormone-dependent 5 cases, recurrent type 7 cases, hormone not