【摘 要】
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Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is the etiologic agent responsible for the global coronavirus disease 2019 (COVID-19) pandemic.Numerous studies have demonstrated that cardiovascular disease may affect COVID-19 progression.In t
【机 构】
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School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products,Kunm
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Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is the etiologic agent responsible for the global coronavirus disease 2019 (COVID-19) pandemic.Numerous studies have demonstrated that cardiovascular disease may affect COVID-19 progression.In the present study,we investigated the effect of hypertension on viral replication and COVID-19 progression using a hypertensive mouse model infected with SARS-CoV-2.Results revealed that SARS-CoV-2 replication was delayed in hypertensive mouse lungs.In contrast,SARS-CoV-2 replication in hypertensive mice treated with the antihypertensive drug captopril demonstrated similar virus replication as SARS-CoV-2-infected normotensive mice.Furthermore,antihypertensive treatment alleviated lung inflammation induced by SARS-CoV-2 replication (interleukin(IL)-1β up-regulation and increased immune cell infiltration).No differences in lung inflammation were observed between the SARS-CoV-2-infected normotensive mice and hypertensive mice.Our findings suggest that captopril treatment may alleviate COVID-19 progression but not affect viral replication.
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