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目的了解急性淋巴细胞白血病(ALL)患儿诱导缓解期医院感染的危险因素。方法对医院儿科血液组2005年1月-2011年8月住院治疗的374例初发ALL患儿进行回顾性调查研究,对发生医院感染病例进行单因素检验和多因素的非条件logistic回归分析。结果 374例初发ALL患儿发生医院感染161例,感染率为43.0%,多因素分析得出差异有统计学意义的危险因素分别为:年龄、体重、病房床位数、血红蛋白量、中性粒细胞数。结论白血病患儿诱导缓解期因化疗及住院时间较长,易于发生医院感染,床位数是医院感染的危险因素,年龄、体重、血红蛋白、中性粒细胞数是医院感染的保护因素。
Objective To investigate the risk factors of nosocomial infection in children with acute lymphoblastic leukemia (ALL) during remission. Methods A retrospective study was conducted on 374 children with primary ALL who were hospitalized in pediatric pediatric blood group from January 2005 to August 2011. Unilateral logistic regression analysis and multivariate non-conditional logistic regression analysis were performed on hospital-acquired nosocomial infections. Results Of the 374 newly diagnosed ALL children, nosocomial infection occurred in 161 cases and the infection rate was 43.0%. Multivariate analysis showed that the statistically significant risk factors were age, weight, ward beds, hemoglobin, neutrophil Cell number. Conclusions Patients with leukemia induced remission due to longer chemotherapy and hospital stay, prone to nosocomial infection, the number of beds is a risk factor for nosocomial infection, and age, weight, hemoglobin and neutrophil number are the protective factors of nosocomial infection.