论文部分内容阅读
本文观察硝苯吡啶对大鼠乙醇、消炎痛和幽门结扎三种胃溃疡模型的影响。结果显示该药对消炎痛和幽门结扎所致溃疡具有明显保护作用,与对照组相比,其溃疡面积、数目、发生率及胃损指数均有不同程度降低,其中溃疡面积与硝苯吡啶剂量呈负相关(r_s=-1)。在幽门结扎组,溃疡面积与游离酸度呈正相关(r_s=0.86);硝苯吡啶使Shay大鼠的胃液量、游离酸及总酸度均低于对照组,提示其溃疡防护作用与抑制胃酸分泌有关。该药对乙醇性溃疡无显著影响。
This paper observed the effects of nifedipine on alcoholic rats, indomethacin and pylorus ligation of three gastric ulcer models. The results showed that the drug has obvious protective effect on the ulcer induced by indomethacin and pylorus ligation. Compared with the control group, the ulcer area, the number, the incidence and the gastric lesion index all decreased to some extent. The area of the ulcer and the nifedipine dose Was negatively correlated (r_s = -1). In the pyloric ligation group, the area of ulcer was positively correlated with free acidity (r_s = 0.86). Nifedipine caused gastric juice, free acid and total acidity in Shay rats were lower than those in control group, suggesting that the protective effect of ulcer was related to inhibition of gastric acid secretion . The drug has no significant effect on alcoholic ulcer.