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目的探讨子宫内膜息肉(endometrial polyps,EP)电切术后宫内放置左炔诺孕酮宫内缓释系统(levonorgestrel intrauterine system,LNG-IUS,又称曼月乐)预防息肉复发的临床疗效。方法收集整理2010年1月至2012年5月郑州市妇幼保健院收治的120例EP电切术后患者的临床资料,根据不同处理方法分为对照组45例、黄体酮组40例、曼月乐组35例。比较3组术后出血情况、术后2年EP复发情况。结果术后出血患者比例由高到低依次为:曼月乐组45.7%(16/35)、对照组33.3%(15/45)、黄体酮组22.5%(9/40)。术后2年曼月乐组复发率2.9%(1/35),低于对照组8.9%(4/45)及黄体酮组5.0%(2/40)(P<0.05)。结论 EP电切术后宫内放置LNG-IUS预防息肉复发的疗效显著。
Objective To investigate the clinical efficacy of levonorgestrel intrauterine system (LNG-IUS) in preventing the recurrence of polyp after intrauterine resection of endometrial polyps (EP) . Methods The clinical data of 120 patients after EP resection treated in Zhengzhou Maternal and Child Health Hospital from January 2010 to May 2012 were collected and classified into 45 cases in control group, 40 cases in progesterone group, Music group of 35 cases. The postoperative bleeding was compared between the two groups and EP recurrence was observed 2 years after operation. Results The proportion of postoperative bleeding in descending order was: 45.7% (16/35) in Mirena group, 33.3% (15/45) in control group and 22.5% (9/40) in progesterone group. The recurrence rate of Mirena group was 2.9% (1/35) 2 years after operation, lower than 8.9% (4/45) in control group and 5.0% (2/40) in progesterone group (P <0.05). Conclusion EP resection of intrauterine placement of LNG-IUS to prevent the recurrence of polyps significant effect.