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本文用DSC和激光拉曼光谱研究抗癌药物足叶乙甙(4-去甲基表鬼臼毒素-β-D-乙叉吡喃葡萄糖甙,简称VP 16-213)与二棕榈酰磷脂酰胆碱(DPPC)脂质体的作用。VP 16-213分子掺入DPPC脂质体双层中,不但使相转变温度向高温移动,而且吸热峰的半高宽度随VP 16-213浓度增加而变宽。其Raman光谱在频率2850 cm~(-1)处的C-H键对称伸缩振动亦随着药物浓度增加而减弱。这些结果表明VP 16-213分子是定域在脂双层中DPPC分子链的C_1～C_9亚甲基区域,使脂质体的有序性提高而流动性降低。
In this paper, the anti-cancer drugs etoposide (4-demethylated epipodophyllotoxin-β-D-ethylidene glucopyranoside, referred to as VP 16-213) and dipalmitoylphosphatidylcholine Choline (DPPC) liposomes. Incorporation of VP 16-213 molecules into the DPPC liposome bilayer not only shifted the phase transition temperature to high temperature, but also broadened the half width of the endothermic peak with increasing VP 16-213 concentration. The C-H symmetric stretching vibration of Raman spectrum at 2850 cm -1 also decreases with the increase of drug concentration. These results indicate that the VP 16-213 molecule is localized in the C 1 -C 9 methylene region of the DPPC molecular chain in the lipid bilayer, leading to improved liposome order and reduced fluidity.