论文部分内容阅读
目的 :了解表达不同 HLA- B抗原的强直性脊柱炎 ( AS)患者的临床特点及对诊断的意义。方法 :应用微量淋巴细胞毒法对符合 1 984年修订纽约标准的 2 8例 AS患者外周血中单个核细胞表面的 HLA- B2 7,B7,B40 ,B1 3抗原进行检测并分析其与临床的相关性。结果 :HLA- B2 7阳性的患者多以外周关节受累为首发症状且患者平均发病年龄比 HLA- B2 7阴性者小 ,HLA- B2 7阴性的患者往往以腰痛为首发症状 ,发病年龄相对较大。结论 :HLA- B2 7阳性对于以外周关节受累为首发症状、年龄 2 5岁以下的 AS患者诊断意义较大。
Objective: To understand the clinical features and diagnostic significance of ankylosing spondylitis (AS) patients expressing different HLA-B antigens. Methods: The levels of HLA-B2 7, B7, B40 and B1 3 on the surface of mononuclear cells in 28 AS patients who met the New York standards revised in 1994 were detected by using the method of micro-lymphocyte cytotoxicity Correlation. Results: Patients with positive HLA-B2 7 were the first symptom of peripheral joint involvement and the average age of onset was lower than that of HLA-B2 7 negative patients. HLA-B2 7 negative patients often had low back pain as the first symptom and their age of onset was relatively large . Conclusion: The positive HLA-B2 7 is the first symptom of peripheral joint involvement. The diagnosis of AS patients under 25 years of age is of great diagnostic value.