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颅咽管肿瘤手术后和垂体柄切断术后发生尿崩症的三期过程包括最初的多尿期2～5日,继以3～6目的中间期和第二次多尿期,即尿崩症期。在中间期的3～6日中有少尿、尿浓缩和低钠血症,是由于下丘脑神经核损坏而使抗利尿素的分泌失去控制所致。本文报告一例8岁患颅咽管瘤的女孩,手术切除肿瘤后即发生多尿,每小时尿量1800毫升,尿比重1000～1006。为了防止抽筋,给以苯妥英钠,剂量为250毫克一次,125毫克两次。手术后36小时出现中间期,尿量每小时减至5～10毫升,比重上升至1030。尽管立即减少给予液体的量,血钠仍下降到127毫当量/升,患者反应欠佳。遂给以苯妥英钠静脉注射治
Craniopharyngioma surgery and pituitary stalk after cutting off occurred during the three phases of diabetes insipidus, including the first polyuria 2 to 5 days, followed by 3 to 6 mesh intermediate period and second polyuria, that is, diabetes insipidus Symptomatic. In the middle of 3 to 6 days in oliguria, urinary concentration and hyponatremia, is due to damage to the hypothalamic nerve nucleus and the loss of anti-diuretic caused by loss of control. This article reports a case of 8-year-old girl suffering from craniopharyngiomas, polyuria occurred after surgical removal of the tumor, urine output 1800 ml per hour, urine specific gravity of 1000 to 1006. To prevent cramping, give phenytoin sodium at a dosage of 250 mg twice at 125 mg twice. 36 hours after surgery in the middle period, urine output reduced to 5 to 10 ml per hour, the proportion rose to 1030. Despite an immediate reduction in the amount of fluid delivered, the serum sodium dropped to 127 meq / l and patients did not respond well. Then give phenytoin sodium intravenous treatment