论文部分内容阅读
目的:探讨大肠癌患者癌组织中环氧化酶-2(COX-2)、胸苷酸合成酶(TS)的表达及其与患者无病生存期的关系。方法:筛选我院收治的大肠癌根治术患者,选择无病生存期大于48个月者30例和无病生存期小于48个月者29例。采用免疫组化法检测大肠癌组织中COX-2和TS的表达,并分析其与患者无病生存期的关系。结果:49例结直肠癌患者中,TS的阳性表达率为91.84%,COX-2的阳性表达率为77.55%。不同无病生存期的大肠癌患者TS的表达水平比较无统计学差异(P=0.646)。COX-2在无病生存期>48个月的患者癌组织中表达水平明显低于无病生存期<48个月的患者,差异有统计学意义(P=0.033)。结论:COX-2与大肠癌患者的无病生存期显著相关,可能成为预测大肠癌预后的参考指标。
Objective: To investigate the expression of cyclooxygenase-2 (COX-2) and thymidylate synthase (TS) in patients with colorectal cancer and its relationship with disease-free survival. Methods: A total of 29 patients with colorectal cancer undergoing radical surgery were enrolled in this study. Thirty patients with disease-free survival> 48 months and those with disease-free survival> 48 months were selected. Immunohistochemistry was used to detect the expression of COX-2 and TS in colorectal cancer tissues and to analyze the relationship between the expression of COX-2 and TS in patients with disease-free survival. Results: Among 49 cases of colorectal cancer, the positive rate of TS was 91.84% and the positive rate of COX-2 was 77.55%. TS patients with different disease-free survival of colorectal cancer showed no significant difference (P = 0.646). The expression of COX-2 in patients with disease-free survival> 48 months was significantly lower than that in patients with disease-free survival <48 months (P = 0.033). Conclusion: COX-2 is significantly associated with disease-free survival in patients with colorectal cancer and may be a reference index for predicting the prognosis of colorectal cancer.