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目的：观察亚叶酸钙（CF）、氟脲嘧啶（5－FU）、顺铂（DDP）、10－羟基喜树碱（10－HCPT）（HLFP）方案治疗晚期胃肠道癌的效果。方法：采用HLFP联合化疗方案治疗晚期胃癌29例，肠癌18例。CF每天200mg／m2，静脉滴注，连用5天；5－FU每天375mg／m2；静脉持续滴注，连用5天；DDP 80mg／m2，分5天静脉滴注；10－HCPT每天6mg／m2，静脉滴注，连用5天，21天为一周期。结果：胃癌29例，完全缓解（CR）4例，部分缓解（PR）9例，总缓解率44．8％（13例）；肠癌18例，完全缓解（CR）1例，部分缓解（PR）5例，总缓解率30．0％（6例）。不良反应主要是消化道反应、口腔炎和骨髓抑制。结论：氟脲嘧啶持续输注为主的HLFP方案治疗晚期胃癌疗效较高，不良反应轻，可耐受，该方案治疗晚期肠癌疗效未见比CF／5－FU明显提高。
Objective: To observe the effect of leucovorin (CF), fluorouracil (5-FU), cisplatin (DDP) and 10-hydroxycamptothecin (10-HCPT) Methods: HLFP combined with chemotherapy in the treatment of advanced gastric cancer in 29 cases, 18 cases of intestinal cancer. CF daily 200mg / m2, intravenous infusion, once every 5 days; 5-FU daily 375mg / m2; continuous intravenous drip for 5 days; DDP 80mg / m2 intravenous infusion of 5 days; 10-HCPT daily 6mg / m2 , Intravenous drip, once every 5 days, 21 days for a cycle. Results: There were 29 cases of gastric cancer, 4 cases of complete remission (CR), 9 cases of partial remission (PR), the total remission rate was 44.8% (13 cases), 18 cases of colorectal cancer, 1 case of complete remission PR) in 5 cases, the total response rate was 30.0% (6 cases). Adverse reactions are mainly gastrointestinal reactions, stomatitis and myelosuppression. CONCLUSION: The continuous infusion of fluorouracil-based HLFP regimen has the advantages of high efficacy, mild adverse reactions and tolerability. The efficacy of this regimen in the treatment of advanced colorectal cancer was not significantly higher than that of CF / 5-FU.