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干扰素是一种类似多肽激素的细胞功能的调节物质,但它和多肽激素的最大差别是,极微量(10~(-13)或10~(-12)M)即能使细胞呈抗病毒状态。这样比胰岛素等低100倍以上的微量而仍具有生物学活性的物质,究竟如何与其受体系统相互作用?干扰素具有抗病毒、抗肿瘤和调节免疫反应等多种生物学活性,是一种细胞受体,抑或是多种细胞受体参与其活性的表达?干扰素相对的种属特异性如何为受体所决定?干扰素有多样性,其受体是否也有多样性?干扰素携带的信息如何为细胞所接受并传给细胞核?以及研究干扰素受体与提高干扰素的临床疗效是否有关
Interferon is a regulator of cellular function similar to polypeptide hormones, but the biggest difference between it and peptide hormone is that it can make cells appear antiviral in a very small amount (10 ~ (-13) or 10 ~ (-12) M) status. Such as insulin and other 100 times lower than the trace and still biological activity of the substance, how to interact with its receptor system? Interferon has antiviral, anti-tumor and immune response and other biological activity, is a Cell receptor, or a variety of cell receptors involved in the expression of its activity? Interferon relative species specificity is determined by the receptor? Interferon diversity, the diversity of its receptor? Interferon-carrying How cells are accepted and transmitted to the nucleus, and whether interferon receptors are involved in improving the clinical efficacy of interferon