CONSTRUCTION OF A BIVALENT ORAL VACCINE FOR PREVENTION OF TYPHOID FEVER AND CHOLERA DIARRHEA

• 作 者: 马清钧 于秀琴 刘传暄 周建光 熊凌霜 黄翠芬
• 机 构: InstituteofBiotechnology,AcademyofMilitaryMedicalSciences,Beijing100850,PRC,PRC
• 出 处: Science in China,Ser.B
• 发表日期: 1990年1期
• 关键词: cholera Vibrio subunit vaccine diarrhea plasmid killed retained attenuated Salmo

A recombinant plasmid pMM-CTB containing the gene for production of the nontoxic B subunit of Vibrio cholera was transferred into a safe, effective and attenuated oral vaccine Ty21a strain of Salmonella typhi. The resulting Ty21a(pMM-CTB) could steadily p