论文部分内容阅读
目的探讨子宫内膜胎盘蛋白14(PP14)在子宫内膜异位症(EM)患者中的诊断价值。方法选取50例EM患者为研究组,对照组为体检正常的30例女性。采用ELISA法测定EM各组血清及腹水中PP14和对照组各组血清PP14水平。结果 (1)轻型EM组增生期血清PP14高于对照组增生期(P<0.05);轻型EM组分泌期血清PP14和对照组分泌期比较,差异无统计学意义(P>0.05)。重型EM组增生期和分泌期血清PP14均高于对照组(均P<0.05)。在分泌期和增生期,EM组血清PP14表达水平均为重型组高于轻型组(P<0.05)。在增生期EM组PP14腹水表达水平重型组和轻型组差异无统计学意义(P>0.05);在分泌期EM组PP14腹水表达水平重型组高于轻型组(P<0.05)。(2)EM组血清PP14和腹水PP14水平呈直线正相关(r=0.674,P<0.01)。结论 PP14在EM的发生发展中起一定作用,血清PP14可能成为诊断EM的新的血清学指标。
Objective To investigate the diagnostic value of endometrial placental protein 14 (PP14) in patients with endometriosis (EM). Methods Fifty patients with EM were selected as the study group and the control group as 30 normal women. The levels of serum PP14 in serum and ascites of EM groups and the control group were determined by ELISA. Results (1) The level of PP14 in the light EM group during proliferative phase was higher than that in the control group (P <0.05). There was no significant difference in the secretion of PP14 between the light EM group and the secretory phase of the control group (P> 0.05). In severe EM group, the levels of PP14 in proliferative and secretory phases were higher than those in control group (all P <0.05). In secretory phase and proliferative phase, the levels of PP14 in EM group were significantly higher than those in the light group (P <0.05). There was no significant difference in the level of ascites in PP14 between the EM group and the control group (P> 0.05). In the secretory phase, the expression level of ascites in the PP14 group was higher than that in the light group (P <0.05). (2) There was a linear positive correlation between serum PP14 level and PP14 level in EM group (r = 0.674, P <0.01). Conclusion PP14 plays a role in the development of EM. Serum PP14 may be a new serological marker for the diagnosis of EM.