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为阐明口服补锌对利福平致肝损害的影响 ,采用利福平 ip 50 mg· kg-1· d-1,连续 2 1 d,造成大鼠肝损害模型 .同时口服硫酸锌液 ,每只大鼠 1 .2mg·d-1连续 2 1 d.结果发现单独给予利福平可使大鼠血清和肝脏中脂质过氧化产物及血清谷丙转氨酶水平升高 ,病理学检查也发现明显肝损害 .同时补锌则可拮抗利福平所致大鼠血清和肝脏中脂质过氧化产物及血清谷丙转氨酶水平升高 ,提高肝脏金属硫蛋白水平 ,肝脏病理学检查也有明显改善 .提示锌对利福平致肝损害有一定预防作用 .
In order to elucidate the effects of oral zinc supplementation on the liver damage caused by rifampicin, a rat model of liver damage was established with rifampicin ip 50 mg · kg-1 · d-1 for 21 consecutive days.At the same time, Only rats 1 · 2mg · d-1 for 21 days continuously.It was found that rifampicin alone could increase lipid peroxidation products and serum alanine aminotransferase in serum and liver of rats, and also found obvious pathological examination Liver damage.At the same time zinc supplementation can antagonize rifampin-induced serum and liver lipid peroxidation products and serum alanine aminotransferase levels, improve the level of liver metallothionein, liver pathology also significantly improved. Zinc on rifampin-induced liver damage have a preventive effect.