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目的:观察鼠神经生长因子联合前列地尔、α-硫辛酸治疗糖尿病周围神经病变临床效果。方法:选DPN患者67例,随机分为治疗组、对照组。对照组予前列地尔、α-硫辛酸治疗,治疗组在上述基础上加鼠神经生长因子治疗,3周为一个疗程,观察两组治疗前、后的临床疗效,运动神经传导速度(MNCV)的变化情况。结果:治疗组临床疗效总有效率84.84%,高于对照组61.76%(P<0.05);两组治疗后较治疗前MNCV均改善(P<0.05),治疗组优于对照组(P<0.05)。结论:鼠神经生长因子联合前列地尔、α-硫辛酸治疗糖尿病周围神经病变疗效确切,值得临床应用。
Objective: To observe the clinical effect of nerve growth factor combined with alprostadil and α-lipoic acid in the treatment of diabetic peripheral neuropathy. Methods: 67 patients with DPN were randomly divided into treatment group and control group. The control group was treated with alprostadil and α-lipoic acid. The treatment group was treated with mouse nerve growth factor on the basis of above for 3 weeks. The clinical curative effect, motor nerve conduction velocity (MNCV) Changes in the situation. Results: The total effective rate of the treatment group was 84.84%, higher than that of the control group (61.76%, P <0.05). The MNCV of both groups were improved after treatment (P <0.05), and the treatment group was better than the control group ). Conclusion: The combination of rat nerve growth factor plus alprostadil and α-lipoic acid in the treatment of diabetic peripheral neuropathy is effective and worthy of clinical application.