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目的： 探讨转移特异性ＣＤ４４ 变体ＣＤ４４Ｖ６ 在鼻咽鳞癌中的表达及其临床意义。方法： 利用免疫组化ＳＰ方法检测５６ 例鼻咽鳞癌石蜡标本中ＣＤ４４Ｖ６的表达，并对其阳性表达与临床因素之间的关系进行探讨。结果：５６例鼻咽鳞癌中ＣＤ４４Ｖ６ 总阳性表达率为６２５ ％ 。Ⅰ－ Ⅱ期与Ⅲ－ Ⅳ期鼻咽鳞癌之间，高中分化与低分化鳞癌之间ＣＤ４４Ｖ６阳性表达率均无明显差别（ Ｐ＞ ００５） ；ＣＤ４４Ｖ６阳性率在有颈淋巴结转移组和无颈淋巴结转移组之间也无明显差别。远处转移组ＣＤ４４Ｖ６ 阳性率明显高于非远处转移组（ Ｐ＜ ００５） ；放疗后生存５ 年以上组ＣＤ４４Ｖ６ 阳性率明显低于生存５ 年以下组（ Ｐ＜ ００５） 。结论： ＣＤ４４Ｖ６ 的阳性表达与鼻咽鳞癌病人的远处转移及预后不良有关，并可作为判断鼻咽鳞癌生物学行为和预后的一个有用指标
Objective: To investigate the expression of metastasis-specific CD44 variant CD44V6 in nasopharyngeal squamous cell carcinoma and its clinical significance. Methods: The expression of CD44V6 in 56 specimens of nasopharyngeal squamous cell carcinoma was detected by immunohistochemical SP method, and the relationship between the expression of CD44V6 and clinical factors was also discussed. Results: The total positive expression rate of CD44V6 in 56 cases of nasopharyngeal squamous cell carcinoma was 625%. There was no significant difference in the positive rates of CD44V6 expression between stage Ⅰ-Ⅱ and stage Ⅲ-Ⅳ nasopharyngeal squamous cell carcinoma (P> 0.05). The positive rate of CD44V6 in cervical lymph node metastasis group There was also no significant difference between the groups with or without cervical lymph node metastasis. The positive rate of CD44V6 in distant metastasis group was significantly higher than that in non-distant metastasis group (P <005). The positive rate of CD44V6 in the group of survival more than 5 years after radiotherapy was significantly lower than that in the group of survival less than 5 years (P <005). Conclusion: The positive expression of CD44V6 is associated with distant metastasis and poor prognosis of patients with nasopharyngeal squamous cell carcinoma and may be used as a useful index to judge the biological behavior and prognosis of nasopharyngeal squamous cell carcinoma