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目的:探讨碱性成纤维细胞生长因子治疗感音神经性聋的临床应用价值及鼓室局部给药的可行性。方法:随机选择本院1998～1999年收治的感音神经性聋患者40例(50耳),碱性成纤维细胞生长因子(bFGF)作鼓膜穿刺鼓室内给药。治疗前后进行纯音测听,定期随访,追踪观察bFGF的疗效。结果:经bFGF治疗后,患者语频、高频及0.25～4 kHz各频率的听阈平均值均有明显提高,分别与治疗前比较,差异有极显著性意义(P<0.01)。总有效率为96％,其中治愈率8％,显效率38％,好转率50％。除有轻度胀痛外,无其他不良反应。结论:鼓室局部应用bFGF治疗感音神经性聋疗效明显,方法可行。
Objective: To investigate the clinical value of basic fibroblast growth factor in treatment of sensorineural hearing loss and the feasibility of topical administration to the tympanic cavity. Methods: Forty patients (50 ears) with sensory neuropathy who were admitted to our hospital from 1998 to 1999 were randomly selected, and basic fibroblast growth factor (bFGF) was used as tympanic membrane for tympanic administration. Before and after treatment of pure tone audiometry, regular follow-up, follow-up observation of bFGF efficacy. Results: After treatment with bFGF, the average hearing threshold of patients at speech frequency, high frequency and 0.25 ~ 4 kHz were significantly higher than that before treatment, respectively (P <0.01). The total efficiency of 96%, of which 8% cure rate, markedly efficient 38%, improvement rate of 50%. In addition to mild pain, no other adverse reactions. Conclusion: The tympanic local application of bFGF treatment of sensorineural hearing loss obvious effect, the method is feasible.