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利用正交设计的数学方法进行实验设计，用传统的溶剂蒸发法制备聚乳酸（ＰＬＡ）微球，考察不同因素（即工艺参数）对微球平均粒径大小（即指标）的影响，寻找制备不同粒径微球的最佳条件，所考察的因素分别为分散剂聚乙烯醇（ＰＶＡ）浓度、聚乳酸浓度、搅拌速度、分散相（油相）与连续相（水相）体积比；并考虑了因素间可能有的交互作用，即分散剂浓度与聚乳酸浓度之间、与油／水相体积比之间、聚乳酸浓度与油／水相体积比之间的交互作用。结果表明４因素对平均粒径大小影响的主次顺序分别为：搅拌速度、分散剂浓度、聚乳酸浓度、油相和水相体积比。其中，聚乳酸浓度与油／水相体积比间的交互作用是交互作用中对平均粒径影响最大的
The orthogonal design was used to design the experiment. The traditional solvent evaporation method was used to prepare polylactic acid (PLA) microspheres. The effects of different factors (ie process parameters) on the average size of the microspheres (ie index) The optimal conditions for the microspheres with different diameters were as follows: polyvinyl alcohol (PVA) concentration, polylactic acid concentration, stirring speed, volume ratio of disperse phase (oil phase) to continuous phase (water phase) The possible interactions between factors are considered, namely the interaction between dispersant concentration and polylactic acid concentration, and oil / water phase volume ratio, between polylactic acid concentration and oil / water phase volume ratio. The results showed that the order of the four factors influencing the average particle size were as follows: stirring speed, dispersant concentration, concentration of polylactic acid, volume ratio of oil phase to water phase. Among them, the interaction between the concentration of polylactic acid and the volume ratio of oil / water phase has the greatest influence on the average particle size during the interaction