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本文通过体内及体外实验观察了纳络酮对正常、缺血和再灌注心肌腺苷酸环化酶（AC）活性的影响。其结果表明：静脉注射纳络因（1mg．kg-1）可以明显降低缺血、再灌注心肌AC活性（P＜0．01，P＜0．05）；但纳络酮在体外对正常、缺血和再灌注心肌组织匀浆AC活性无明显抑制作用（P＞0．05）。提示：纳络酮本身对AC活性无直接抑制作用，它降低缺血、再灌注心肌AC活性可能与酶前调节有关。
In this paper, the effects of naloxone on adenylyl cyclase (AC) activity in normal, ischemic and reperfused myocardium were observed in vitro and in vivo. The results showed that intravenous injection of Nalox (1mg.kg-1) could significantly decrease the AC activity of myocardial ischemia and reperfusion (P <0.01, P <0.05) There was no significant inhibitory effect on AC activity in myocardial homogenate of ischemia and reperfusion (P> 0.05). Tip: naloxone itself has no direct inhibitory effect on AC activity, it reduces ischemia, reperfusion myocardial AC activity may be related to pre-enzyme regulation.