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目的探究围手术期中强化他汀治疗对肾动脉狭窄介入治疗后的炎性因子以及肾功能方面的影响。方法方便选取菏泽鲁心医院、济南市中心人民医院等院于2013年12月—2016年3月接受肾动脉狭窄手术治疗的患者280例,采用随机分组的方式将患者平均分成实验组和观察组,在手术前后分别观察患者的炎性因子水平以及反映肾功能的指标,并对两组患者进行对比分析。结果在围手术期中采用强化他汀治疗的实验组患者的CRP、IL-6的值、炎性因子水平分别(5.17±2.07)、(25.58±3.96)和(163.67±5.31),而采用常规治疗的对照组中的CRP、IL-6、血肌酐值在手术后的值分别为(6.35±1.95)、(32.12±4.73)和(169.75±5.19),手术后CRP、IL-6的值,血肌酐值水平差异有统计学意义,P<0.05。结论在围手术期中强化他汀治疗有助于对肾动脉狭窄介入治疗后炎性因子及肾功能的改善,具有显著疗效。
Objective To investigate the effect of perioperative intensive statin therapy on inflammatory factors and renal function after interventional treatment of renal artery stenosis. Methods Convenient selection Heze Lu Xin Hospital, Jinan Central People’s Hospital and other hospital from December 2013 to March 2016 280 patients undergoing renal artery stenosis were randomly divided into groups were divided into experimental group and observation group The levels of inflammatory cytokines and indexes of renal function were observed before and after surgery. The two groups of patients were compared. Results The levels of CRP, IL-6 and the levels of inflammatory cytokines in the experimental group receiving intensive statin treatment during the perioperative period were (5.17 ± 2.07), (25.58 ± 3.96) and (163.67 ± 5.31), respectively, The postoperative values of CRP, IL-6 and serum creatinine in the control group were (6.35 ± 1.95), (32.12 ± 4.73) and (169.75 ± 5.19), respectively. The levels of CRP and IL-6, serum creatinine There were significant differences in value, P <0.05. Conclusion Perioperative intensive statin therapy is helpful for the improvement of inflammatory factors and renal function after interventional treatment of renal artery stenosis.