论文部分内容阅读
目的 制作猪肾盂肾炎和肾脏瘢痕动物模型 ,评价99Tcm 二巯基丁二酸 (DMSA)肾脏平面显像和SPECT断层显像诊断肾盂肾炎和肾脏瘢痕的灵敏度和特异性 ,并探讨SPECT的诊断价值。方法 中国实验动物小型猪 13只 ,先制成膀胱输尿管返流动物模型 ,然后引入大肠埃稀杆菌导致上尿路感染 ,感染前后用ADACVertex型双探头SPECT仪 ,配低能高分辨率准直器进行肾脏前后位平面和断层显像 ,将显像结果同组织病理学检查进行对比研究。结果 平面显像诊断肾盂肾炎和肾脏瘢痕的灵敏度为 71 2 % ,特异性为 10 0 % ,准确性为 87 5 % ;平面加断层显像诊断肾盂肾炎和肾脏瘢痕的灵敏度为 78 3% ,特异性为 10 0 % ,准确性为 90 5 %。以病理检查为标准 ,平面显像和平面加断层显像对病灶的检出率差异无显著性。结论 99Tcm DMSA肾脏显像是诊断肾盂肾炎和肾脏瘢痕的灵敏可靠方法。平面加断层显像可能有助于提高检测的灵敏度 ,并对病变范围作更准确的估价
Objective To develop porcine pyelonephritis and animal model of renal scar to evaluate the sensitivity and specificity of 99Tcm dimercaptosuccinic acid (DMSA) renal plain imaging and SPECT imaging in the diagnosis of pyelonephritis and renal scar, and to explore the diagnostic value of SPECT. Methods Thirteen Chinese miniature pigs were used to make the animal model of vesicoureteral reflux and then introduced into Escherichia coli to induce upper urinary tract infection. Before and after infection, ADACVertex double-probe SPECT was used with low-energy and high-resolution collimator Renal anterior and posterior planes and tomographic imaging, the imaging results were compared with histopathological examination. Results The sensitivity of plain imaging in the diagnosis of pyelonephritis and renal scar was 71.2%, specificity was 100% and accuracy was 87.5%. The sensitivity of plain plus tomography in the diagnosis of pyelonephritis and renal scar was 78.3% Sex is 10%, accuracy is 90 5%. Pathological examination as the standard, flat imaging and plain plus tomography on the detection rate of lesions was no significant difference. Conclusion 99Tcm DMSA renal imaging is a sensitive and reliable method for the diagnosis of pyelonephritis and renal scar. Plane plus tomography may help to increase the sensitivity of the detection and make a more accurate assessment of the extent of the lesion