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卵细胞缺乏或卵细胞对促性腺激素无反应可以导致过早绝经,为鉴别诊断作卵巢活检是必要的,假如在活检中发现有滤泡,则提示滤泡中缺乏促性腺激素受体,如发现有极少滤泡则是快速闭锁的原始滤泡(Tur-ner综合征存此现象)或早期破坏的滤泡(该现象在化学治疗和放疗之后或自体免疫性疾病中发生),必须注意到有潜在病因的可能性。本报告病人是X染色体长臂末端小的缺失而致过早绝经,她母亲也有同样的缺失和过早绝经。此报告不仅文献中少见类似的病例,而且家族性表现也较罕见。
Lack of egg cells or egg cells without response to gonadotropins can lead to premature menopause, for the differential diagnosis of ovarian biopsy is necessary, if found in the biopsy follicles, prompted the lack of follicle gonadotropin receptor, if found to have Minimal follicles are rapidly occluding primary follicles (Tur-ner syndrome) or early ruptured follicles (this occurs after chemoradiation and radiotherapy or in autoimmune diseases) and it must be noted that there are Potential causes of the disease. The reported patient is a small deletion of the long arm of the X chromosome that leads to premature menopause, and her mother has the same deletions and premature menopause. This report not only rare in the literature similar cases, and familial performance is also rare.