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本文描述糖醇如甘露醇、山梨醇、乳精醇和肌醇对MCNU[1-2(氯乙基)-3-(甲α-D-吡喃萄糖-6yl)-1-亚硝脲]致命性毒性的降低作用。同时,对其他抗肿瘤药如GANU、ACNU、Me-CCNU和丝裂霉素C的类似作用也进行了观察。作者研究了小鼠急性致死性毒性、骨髓抑制作用、对体外培养的肿瘤细胞抑制作用以及体内抗肿瘤活性,结果如下: 1.糖醇对MCNU急性致死性毒性的作用:6只雌性CDZF_1小鼠ip50mg/kgMCNU,7～10天后,全部中毒死亡;当以糖醇ip3000mg/kg与MCNU合并应用时,30多天后无一死亡。口服糖醇后存活率也可达33～50%。给予甘露醇300mg/kg,经30天,6只小鼠中3只存活;山梨醇1000mg/kg时,30天存活率为50%,效果较甘露醇低。
Described herein are the effects of sugar alcohols such as mannitol, sorbitol, lactitol and inositol on MCNU [1-2 (chloroethyl) -3- (alpha-D-pyranosyl-6yl) Reducing lethal toxicity. At the same time, similar effects on other antineoplastic agents such as GANU, ACNU, Me-CCNU and mitomycin C were also observed. The authors investigated acute lethal toxicity in mice, myelosuppression, inhibition of tumor cells cultured in vitro, and in vivo antitumor activity with the following results: 1. Effect of sugar alcohols on MCNU acute lethality: Six female CDZF1 mice ip50mg / kgMCNU, 7 to 10 days after all the poisoning death; when combined with sugar alcohol ip3000mg / kg MCNU application, no death after 30 days. Oral sugar alcohol survival rate up to 33 ~ 50%. Mannitol 300mg / kg given 30 days, six mice in three survived; sorbitol 1000mg / kg, 30-day survival rate of 50%, the effect is lower than mannitol.