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本文对28例慢乙肝病人的外周血单个核细胞进行ConA诱生γ干扰素的测定,同时用T细胞单克隆抗体系统检测其T细胞亚群。结果发现,慢乙肝病人ConA诱生的γ干扰素效价为7.858±1.483log2U/ml,而正常对照组为7.839±0.621log2U/ml,两组间无显著性差异,但在慢乙肝病人组内个体间IFN-γ的效价差别显著大于对照组(P<0.05).慢乙肝病人组T细胞亚群的T_4/T_3比例与对照组无显著差异。但IFN-γ反应低下组的5人均有T_4/T_3比例异常。在28例病人中有14例T_4/T_3比例异常(高于或低于正常),且20例HBeAg阳性病人中有12例T_4/T_3比例异常;8例HBeAg阴性病人中仅2例T_4/T_3比例异常。
In this paper, 28 cases of chronic hepatitis B patients with peripheral blood mononuclear cells ConA induced interferon gamma, T cell monoclonal antibody system T cell subsets. The results showed that IFN-γ titer induced by ConA in chronic hepatitis B patients was 7.858 ± 1.483log2U / ml, while it was 7.839 ± 0.621log2U / ml in normal controls, but there was no significant difference between the two groups. However, in patients with chronic hepatitis B There was no significant difference in T_4 / T_3 ratio between T-cell subsets and control group in chronic hepatitis B patients (P <0.05). However, there were abnormal T_4 / T_3 ratios in 5 of the patients with low IFN-γ response. Of the 28 patients, 14 had T_4 / T_3 abnormalities (higher or lower than normal), and 12 of 20 HBeAg positive patients had abnormal T_4 / T_3 ratio; only 2 of 8 HBeAg negative patients showed T_4 / T_3 Abnormal ratio.