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利用N-乙酰-L-半胱氨酸(NAC)作为稳定剂,合成了荧光性质良好的水溶性近红外发射的PbS量子点。系统考察了水相合成PbS量子点的主要影响因素,并通过TEM和XRD分别对其形貌和结构进行表征。结果表明,通过改变前体物质Pb/S,Pb/NAC的摩尔比以及溶液的初始pH值,合成的PbS量子点显示强的近红外荧光,荧光发射峰在895nm到970 nm间可调,表现出明显的量子尺寸效应。通过小鼠近红外成像实验初步证实本实验中合成的PbS量子点在生物医学成像,尤其在体内无损在位成像中具有良好的应用前景。
Using N-acetyl-L-cysteine (NAC) as a stabilizer, a water-soluble near-infrared emitting PbS quantum dot with good fluorescence properties was synthesized. The main influencing factors for the synthesis of PbS quantum dots in aqueous solution were systematically investigated. Their morphology and structure were characterized by TEM and XRD. The results show that by changing the molar ratio of Pb / S, Pb / NAC precursors and the initial pH value of the solution, the synthesized PbS QDs show strong near-infrared fluorescence and the fluorescence emission peak is tunable between 895 nm and 970 nm. The obvious quantum size effect. Near infrared imaging experiments in mice preliminary confirmed that the PbS quantum dots synthesized in this experiment in biomedical imaging, especially in vivo lossless in situ imaging has good prospects.