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肿瘤坏死因子（ＴＮＦ）和Ｏｋａｄａｉｃａｃｉｄ（ＯＡ）能诱发人神经母细胞瘤ＳＫ细胞死亡，死亡细胞缩小变圆，细胞质凝聚，ＤＮＡ断裂形成以２００ｂＰ左右为单位的梯形分布，且上述过程可由蛋白质合成抑制剂亚胺环己酮（ＣＨＸ）抑制，显示ＴＮＦ和ＯＡ诱发的ＳＫ细胞死亡为细胞程序死亡．
Tumor necrosis factor (TNF) and Okadaicacid (OA) can induce the death of human neuroblastoma SK cells, the rounding of dead cells, the condensation of cytoplasm and the formation of a trapezoid distribution with about 200bp DNA breaks, and the above process can be inhibited by protein synthesis Inhibitors of imine cyclohexanone (CHX) inhibition showed that TNF and OA-induced SK cell death was apoptotic.