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目的通过对上海、杭州、南京、武汉、成都和重庆1998～2002年各种抗抑郁药临床用量的变化趋势分析,为合理用药与药品计划生产提供参考依据。方法调研6市近5年抗抑郁药使用状况,以金额为统计依据,计算并比较各药在各年用量比例。结果涉及18种药品,呈上升、下降趋势的分别为7种、10种,波动的1种。SNRI类的文拉法辛上升幅度最大,RIMA类的吗氯贝胺下降趋势最明显。结论随着抗抑郁药临床药理研究的进展,抑郁症的5羟色胺和去甲肾上腺素假说已得到普遍认同,具有双重阻断作用的文拉法辛越来越被临床重视。
Objective To analyze the changing trend of the clinical dosage of various antidepressants in Shanghai, Hangzhou, Nanjing, Wuhan, Chengdu and Chongqing from 1998 to 2002, and to provide a reference for rational drug use and planned drug production. Methods Investigate the use of antidepressants in 6 cities for the past five years. Calculate and compare the proportion of each drug in different years with the amount as the statistical basis. Results involving 18 kinds of drugs, were rising, the downward trend of 7 species, 10 species, a fluctuation. Venlafaxine in the SNRI category showed the largest increase, while the decline in the RIMA category of moclobemide was most pronounced. Conclusion With the progress of the clinical pharmacology of antidepressants, the serotonin and norepinephrine hypothesis of depression has been generally accepted, and the double blocking effect of venlafaxine is more and more clinically valued.