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目的:观察灵通散的抗痛经作用及探讨可能的作用途径。方法:连续灌胃给药,观察灵通散对抗缩宫素或PGF2α诱发的小鼠扭体反应以及抗炎、镇痛、镇静及活血化瘀作用。结果:灵通散对缩宫素或PGF2α诱发的小鼠扭体反应有较好的对抗作用;对小鼠热板法所致物理性疼痛有较好的镇痛效果;对小鼠二甲苯法引起的炎症有抑制作用;与戊巴比妥钠有一定的协同作用;灵通散还能降低缩宫素致痛经模型大鼠体外血栓干重和湿重。结论:灵通散治疗痛经作用显著,可能通过抗炎、镇痛、镇静及活血化瘀抗血栓形成发挥治疗作用。
Objective: To observe the effect of Lingtongsan on dysmenorrhea and to explore the possible ways of action. METHODS: Continuous gavage administration was performed to observe the effect of Lingtong Powder on the writhing response induced by oxytocin or PGF2α and anti-inflammatory, analgesic, sedative, and blood circulation. RESULTS: Lingtong Powder had good antagonistic effect on twitch response induced by oxytocin or PGF2α; it had better analgesic effect on physical pain caused by mouse hot plate method; and it was caused by mouse xylene method. The inflammation has an inhibitory effect; it has a certain synergistic effect with pentobarbital sodium; Lingtongsan can also reduce the thrombus dry weight and wet weight in vitro of oxytocin-induced dysmenorrhea model rats. Conclusion: Lingtong Powder has a significant effect on the treatment of dysmenorrhea and may play a therapeutic role through anti-inflammatory, analgesic, sedative and anti-thrombotic effects of blood circulation.