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迄今在雄性大鼠的实验中已发现,接触石油产物与肾脏毒性和肾癌有关。在七十年代中期使用各种石油、石脑油的亚慢性吸入实验曾观察到雄性大鼠出现肾脏变性,但当时并未引起很大的注意。因为这一作用比较微弱,而且雄性大鼠易于患肾脏疾病,通常称为“老年大鼠肾病”。该肾病是老年大鼠(特别是雄性大鼠)肾脏退行性变,这可能掩盖烃化物引起的肾病。近年来,在两年的实验中使大鼠和小鼠吸入全部汽化的无铅汽油,结果发现,雄性大鼠的肾脏损伤和肾癌的发生率与吸入汽油的剂量相关;雌性小鼠肝脏肿瘤的发生率增加。
Hitherto experiments in male rats have found that exposure to petroleum products is associated with renal toxicity and renal cancer. Subchronic inhalation experiments using various oils and naphthas in the mid-1970s observed renal degeneration in male rats, but at the time did not attract much attention. Because this effect is weak, and male rats are prone to kidney disease, they are often called “old rat kidney disease.” This nephropathy is a degenerative kidney in older rats, especially in male rats, which may mask hydrocarbon-induced nephropathy. In recent years, rats and mice inhaled all vaporized lead-free petrol in two years of experiments. As a result, it was found that the incidence of renal damage and renal cancer in male rats correlated with the dose of inhaled gasoline; and that of female mice with liver tumors The incidence of increased.