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目的 :探讨靶组织内 (胎盘、胎膜、子宫下段 )雌激素受体 (ER)、孕激素受体 (PR)的含量变化和过期妊娠的关系。方法 :对过期妊娠 ( 4 1,3/ 7～ 4 2 ,2 / 7周 )择期剖宫产 10例 (实验组 ) ,并与足月妊娠 ( 38～ 4 0周 ,宫颈评分 7分以上 )择期剖宫产 10例相对照 (对照组 )。分别在术中取胎盘、胎膜、子宫下段组织 ,采用免疫组化法检测ER、PR含量。结果 :①过期妊娠胎盘内ER含量低于对照组 ,差异显著 ,χ2 =6 67(P <0 0 1)。而胎膜、子宫下段内ER值与对照组比较 ,无显著差异 ,P均 >0 0 5。②两组各部位靶组织PR含量与对照组比较 ,均无显著差异 ,P >0 0 5。③两组靶组织ER/PR值比较 ,过期妊娠组胎盘、胎膜ER/PR值均低于对照组 ,差异显著 ,t =2 38,P <0 0 5;t =2 2 6,P <0 0 5,而子宫下段ER/PR值与对照组比较无显著差异 ,P >0 0 5。结论 :胎盘、胎膜ER、PR含量变化和过期妊娠发生有关 ,尤其是胎盘内ER水平降低和过期妊娠关系密切。而子宫下段内ER、PR含量对过期妊娠似乎无影响
Objective: To investigate the relationship between the changes of estrogen receptor (ER) and progesterone receptor (PR) in target tissues (placenta, fetal membranes and lower uterine segment) and overdue pregnancy. Methods: Elective cesarean section was performed in 10 cases (experimental group) of overdue pregnancy (41, 37-42, 27 weeks) and full-term pregnancy (38-400 weeks, cervical score of 7 points or more) Elective cesarean section in 10 cases of relative control (control group). Placenta, fetal membranes and lower uterine tissue were removed intraoperatively, and the contents of ER and PR were detected by immunohistochemistry. Results: ① The content of ER in the placenta of pregnant women with obesity was lower than that of the control group (χ2 = 6 67, P <0.01). The fetal membrane, uterine segment ER value compared with the control group, no significant difference, P> 0.05. ② There was no significant difference in the PR content of target tissues between the two groups as compared with the control group (P> 0.05). ③ The ER / PR value of target tissue in two groups was significantly lower than that in control group (P <0.05) 0 0 5, while the lower uterine ER / PR value compared with the control group no significant difference, P> 0 0 5. CONCLUSION: The changes of placenta, fetal membranes ER and PR are related to the occurrence of overdue pregnancies. In particular, the decrease of placental ER level is closely related to the outdated pregnancy. The lower uterine segment ER, PR content seems to have no effect on the outdated pregnancy