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目的 :探讨葛根素对急性脑梗死患者血清中可溶性细胞间粘附分子 1(sICAM 1)和肿瘤坏死因子 α(TNF α)的影响。方法 :72例急性脑梗死患者随机分为葛根素组及常规组 ,观察治疗前后血清sICAM 1及TNF α水平的变化 ,并与正常组比较。结果 :治疗前血清sICAM 1和TNF α水平较正常组明显升高 (P <0 .0 1) ,治疗后明显降低 (P <0 .0 1) ,但仍高于正常组 (均P <0 .0 1) ,其中葛根素组下降幅度较常规组大 (P <0 .0 5 )。结论 :TNF α、sICAM 1可能参与脑梗死的发病过程 ,葛根素能显著降低急性脑梗死患者血清sICAM 1、TNF α的水平。
Objective: To investigate the effect of puerarin on serum soluble intercellular adhesion molecule 1 (sICAM 1) and tumor necrosis factor α (TNF α) in patients with acute cerebral infarction. Methods: Seventy-two patients with acute cerebral infarction were randomly divided into puerarin group and conventional group. The changes of serum sICAM 1 and TNFα levels before and after treatment were observed and compared with those in normal group. Results: The levels of sICAM 1 and TNFα in serum before treatment were significantly higher than those in normal group (P <0.01), but were significantly lower than those in normal group (P <0.01) .0 1), in which puerarin decreased more than the conventional group (P <0.05). CONCLUSION: TNF α and sICAM 1 may be involved in the pathogenesis of cerebral infarction. Puerarin can significantly reduce the serum levels of sICAM 1 and TNF α in patients with acute cerebral infarction.