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总黄酮作为骨碎补的重要单体具有多项生理作用,能明显提高原发性骨质疏松症患者的骨密度,抑制骨吸收,减少骨量丢失,可以调节下丘脑—垂体—性腺轴功能,改善骨调节激素的紊乱状态,通过多条信号通路介导骨重建机制。总黄酮能否通过直接调节铁调素的表达而影响骨重建目前国内外尚无研究,探究骨碎补总黄酮和铁调素相结合治疗骨质疏松症将达到叠加效应,进一步提高其治疗效果,同时将铁代谢的干预作为治疗骨质疏松的方法尚属首次。
Total flavonoids, as an important monomer of Osteopractic, have many physiological functions and can significantly improve bone mineral density, inhibit bone resorption, decrease bone loss, and regulate hypothalamic-pituitary-gonadal axis function in patients with primary osteoporosis , Improve the regulation of bone disorders hormones, through a number of signaling pathways mediate bone remodeling mechanism. Whether total flavonoids can affect bone remodeling by directly regulating the expression of hepcidin At present, there is no research at home and abroad to explore the superposition effect of total flavonoids of osteoporotia and hepcidin in the treatment of osteoporosis and further improve the therapeutic effect , While the iron metabolism intervention for the treatment of osteoporosis is the first time.