Synthesis of New Flavanone Derivatives of Farrerol and Preliminary SAR Studies on Anti-VSMCs Vegetat

• 作 者: SHI Lei FENG Xiu-e LIN Wen-han
• 机 构: SchoolofPharmaceuticalScience,StateKeyLaboratoryofNaturalandBiomimeticDrugs,InstituteofMateriaMedica
• 出 处: 高等学校化学研究：英文版
• 发表日期: 2011年2期
• 关键词: 血管平滑肌细胞 合成化合物 黄酮衍生物 植被活动 特区 黄烷 VSMC 生物活性 Synthesis Flavanone derivative Anti-V
• 基金项目: Supported by the National High-Tech Research and Development Program of China（No.2006AA09Z446）, the Fund of State Key Laboratory of Natural and Biomimetic Drags, Peking University, China（No.20080210）,

A series of new flavanone derivatives of farrerol was designed and synthesized as a potent inhibitor of vascular smooth muscle cells(VSMCs) vegetation according to a convenient method. The structures of all the synthesized compounds were confirmed by 1H N