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氟啶酸(Enoxacin,ENX)为氟喹诺酮类抗菌药,口服吸收好,抗菌谱广,抗菌活性强,不易产生耐药性,并对其它抗生素的耐药菌有效,且毒副作用小,因此得到临床广泛应用。但随着临床ENX联合用药的增多,有关的药物相互作用也随之出现,本文就ENX与其它药物的相互作用作一简述,以供临床用时参考。 1.茶碱 ENX可抑制肝混合功能氧化酶系统,因而降低茶碱的代谢,可使茶碱的清除率降低为50～60％,服用ENX的患者体内茶碱水平可增加一倍,在部分患者身上可引起茶碱中毒。Davies等曾观察到合用ENX和茶碱的病人中茶碱的严重不良反应发生率异常地增高,
Enoxacin (ENX) is a fluoroquinolone antibacterial agent, which has good oral absorption, broad antibacterial spectrum, strong antibacterial activity, not easy to produce drug resistance, effective against other antibiotic-resistant bacteria and small toxic side effects, Clinical widely used. However, as the clinical ENX combination increases, the related drug interactions also appear. In this article, the interaction between ENX and other drugs is briefly summarized for clinical reference. 1. Theophylline ENX can inhibit liver mixed-function oxidase system, thus reducing the metabolism of theophylline, theophylline can reduce the clearance rate of 50 to 60%, taking the body of theophylline in patients with ENX levels can be doubled in the part The patient can cause theophylline poisoning. Davies et al. Have observed an unusually high rate of serious side effects of theophylline in patients taking ENX and theophylline,