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[目的]观察亮菌甲素联合茵栀黄治疗胆汁瘀积型肝炎的临床疗效。[方法]将68例胆汁瘀积型肝炎患者按不同治疗方法随机分为联合用药组(34例)与对照组(34例)。对照组给予甘利欣30 ml静脉滴注,1次/d;亮菌甲素5 mg静脉滴注(避光),1次/d。联合用药组在对照组相同的治疗基础上用茵栀黄注射液40~60 ml,加10%葡萄糖注射液500 ml静脉滴注,1次/d。2组疗程均为45 d。均于用药后第15、30、45天各测1次肝功能,观察2组治疗后血清总胆红素(Tbil)、γ-谷氨酰转肽酶(GGT)、碱性磷酸酶(AKP)的变化及临床疗效。[结果]用药后第45天Tbil、GGT及AKP下降≥50%的例数,联合用药组较对照组明显增多(P<0.01);联合用药组与对照组的有效率分别为94.1%、61.8%,2组比较P<0.05。[结论]亮菌甲素联合茵栀黄治疗胆汁瘀积型肝炎疗效显著。
[Objective] To observe the clinical effect of srellin A and Yinzhihuang on cholestatic hepatitis. [Method] 68 cases of cholestatic hepatitis were randomly divided into the combined treatment group (34 cases) and the control group (34 cases) according to different treatment methods. The control group was given Gan Lixin 30 ml intravenous infusion, 1 / d; strychnine 5 mg intravenous infusion (dark), 1 / d. Combination therapy group in the control group on the basis of the same treatment with Yin Zhihuang injection 40 ~ 60 ml, plus 10% glucose injection 500 ml intravenous infusion, 1 time / d. The two courses of treatment were 45 d. All the rats were tested for liver function on the 15th, 30th, 45th day after treatment. The levels of total bilirubin (Tbil), γ-glutamyl transpeptidase (GGT), alkaline phosphatase (AKP) ) Changes and clinical efficacy. [Results] The number of cases with more than 50% reduction of Tbil, GGT and AKP on the 45th day after treatment was significantly higher in the combination group than in the control group (P <0.01). The effective rates of the combination group and the control group were 94.1% and 61.8 %, P <0.05 in 2 groups. [Conclusion] The combination of strychnine and Yinzhihuang is effective in treating cholestatic hepatitis.