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目的探讨克拉霉素在呼吸道感染中的临床应用。方法根据克拉霉素的结构特点与药物动力学特征,对克拉霉素在酸性环境中的稳定性、T1/2、在体内的分布、在肝内的代谢、人体生物利用度、抗菌活性等几方面进行了分析。结果克拉霉素为大环内脂类抗生素,具有广谱、稳定、T1/2长,5～7h、组织浓度高,8.5μg/ml、人体生物利用度高50%、抗菌活性强等优点,在临床各科感染疾病治疗中有着广泛的适应症。结论克拉霉素在扁桃体、肺及支气管分泌物中有显著高浓度,对肺组织有亲和力,使其在呼吸道感染治疗中具有较好疗效。
Objective To investigate the clinical application of clarithromycin in respiratory tract infection. Methods According to the structural characteristics and pharmacokinetic characteristics of clarithromycin, the stability of clarithromycin in acidic environment, T1 / 2, in vivo distribution, metabolism in the liver, bioavailability of human body and antibacterial activity Aspects were analyzed. Results Clarithromycin was a macrolide antibiotic with the advantages of broad spectrum, stability, long T1 / 2, 5 ~ 7h, high tissue concentration, 8.5μg / ml, 50% bioavailability and strong antibacterial activity. In the clinical treatment of infectious diseases have a wide range of indications. Conclusion Clarithromycin has a significantly high concentration in tonsils, lung and bronchial secretions, and has an affinity for lung tissue, which makes it have a good therapeutic effect in the treatment of respiratory tract infections.