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目的探讨肌钙蛋白I(cTnI)与CK-MB联合检测对急性心肌梗死(AM I)的临床诊断价值。方法采用罗氏电发光2010自动生化分析仪和日立7180生化分析仪,测定62例AM I患者、50例健康体检者血清的cTnI、肌酸激酶(CK)和CK-MB,并对结果进行统计学分析。结果AM I组血清cTnI、CK和CK-MB高于正常对照组(P<0.01)。cTnI与CK-MB联合检测阳性率为96.7%,高于前三者,且动态检测对早期AM I敏感性更高、阳性持续时间更长。结论肌钙蛋白I与CK-MB联合检测能提高早期急性心肌梗死的检出率,具有更宽的诊断时间窗。
Objective To investigate the clinical value of cTnI and CK-MB in the diagnosis of acute myocardial infarction (AMI). Methods The serum levels of cTnI, creatine kinase (CK) and CK-MB in 62 AMI patients and 50 healthy volunteers were detected by Roche EL 2010 Biochemical Analyzer and Hitachi 7180 Biochemical Analyzer. The results were statistically analyzed analysis. Results The serum levels of cTnI, CK and CK-MB in AMI group were higher than those in normal control group (P <0.01). The positive rate of cTnI and CK-MB was 96.7%, higher than the former three, and the dynamic detection of AMI was more sensitive and longer positive. Conclusions The combined detection of troponin I and CK-MB can improve the detection rate of early acute myocardial infarction with a wider diagnosis window.