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作者从中麻黄(Ephedra intermedia)中分得抗炎有效成分ephedroxane(Ⅰ)。分离方法:干生药6公斤用甲醇浸泡提取5次,每次40升,得提取物830克,混悬于1%H_2SO_4中,用乙醚提取,酸水溶液加碳酸钾至pH11,用乙醚提取,蒸发乙醚液得生物碱部位22.4克,反复用氧化铝层析,以氯仿-甲醇(20:1)洗脱,得结晶流份,用乙醇复结晶得(Ⅰ),为无色针晶,熔点79～81°。经IR,MS和NMR数据分析,证明该新生物碱结构类似于麻黄碱。经麻黄碱制备得噁唑酮衍生物即为ehe-droxane,从而证明其结构如下:
The authors identified Ephedroxane (Ⅰ), an anti-inflammatory active ingredient, from Ephedra intermedia. Separation method: Dried herbs 6 kg soaked with methanol extract 5 times, each 40 liters, 830 grams of extract, suspended in 1% H 2 SO 4, extracted with ether, the acid aqueous solution of potassium carbonate to pH 11, extracted with ether, evaporated Ether solution of alkaloids 22.4 g, repeated with alumina chromatography, chloroform - methanol (20: 1) elution, to obtain a crystalline fraction, ethanol crystallization (I), colorless needles, melting point 79 ~ 81 °. The IR, MS and NMR data analysis showed that the new alkaloid structure is similar to ephedrine. Oxalindone derivative prepared by ephedrine is ehe-droxane, which proves the structure is as follows: