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目的:探析1 d龄先天性心脏病(CHD)新生儿血清神经性特异性烯醇化酶(NSE)磷酸肌酸激酶同工酶(CK-MB)的浓度及临床意义。方法:回顾性分析我院2012年1月至2014年2月1 d龄CHD新生儿50例的临床资料,检测NSE及CK-MB,并与同期50例1 d龄健康新生儿进行对比。结果:CHD患儿的NSE水平(19.6±4.7)ng/mL显著高于对照组(3.9±1.3)ng/mL,CK-MB水平(49.2±5.6)U/L也显著高于对照组(18.8±2.4)U/L,差异均具有统计学意义(均P<0.01)。结论:CHD新生儿的血清NSE及CK-MB水平异常增高,对判断脑部和心肌损伤具有一定临床意义。
Objective: To investigate the serum concentration of neuron specific enolase (NSE) and creatine phosphokinase (CK-MB) in neonates with congenital heart disease (CHD) at 1-d age and its clinical significance. Methods: The clinical data of 50 neonates with CHD from January 2012 to February 2014 in our hospital were retrospectively analyzed. NSE and CK-MB were detected and compared with 50 healthy newborns at 1-day-old in the same period. Results: The NSE level in children with CHD was significantly higher than that in the control group (19.6 ± 4.7) ng / mL and (3.9 ± 1.3) ng / mL and 49.2 ± 5.6 U / L, respectively ± 2.4) U / L, the difference was statistically significant (all P <0.01). Conclusion: The levels of serum NSE and CK-MB in neonates with CHD are abnormally elevated, which is of clinical significance for judging the damage of brain and myocardium.