论文部分内容阅读
目的探讨罗库溴氨在发绀型先天性心脏病患儿临床治疗中的药效。方法选取2014年1月至2015年1月云南省西双版纳州人民医院儿科收治的34例心脏病患儿作为研究对象,其中发绀型先天性心脏病患儿17例,非发绀型先天性心脏病患儿17例,另选取同期收治的行手术治疗的非心脏病患儿17例作为对照组。麻醉诱导后,在患儿上肢前臂静脉快速注入罗库溴氨(0.6 mg/kg)。采用肌松监测仪检测患儿注射后肌松程度,记录3组患儿的罗库溴氨起效时间、作用时间、恢复情况及血红蛋白、血细胞比容。结果发绀型先天性心脏病组患儿的罗库溴氨起效时间明显长于非发绀型先天性心脏病组和对照组,差异有统计学意义(P<0.05);发绀型先天性心脏病患儿的血红蛋白水平、血细胞比容均明显高于非发绀型先天性心脏病组和对照组,差异均有统计学意义(均P<0.05)。结论发绀型先天性心脏病患儿使用罗库溴氨起效时间较长,敏感度低,针对发绀型先天性心脏病患儿实施个体化肌松监测方案是非常必要的。
Objective To investigate the efficacy of rocuronium in the clinical treatment of children with cyanotic congenital heart disease. Methods From January 2014 to January 2015, 34 children with heart disease underwent pediatric treatment in Xishuangbanna People’s Hospital of Yunnan Province. Among them, 17 cases of cyanotic congenital heart disease, 17 cases of non-cyanotic congenital heart disease 17 cases of children, and the other selected the same period of surgical treatment of non-cardiac patients treated 17 cases as a control group. After induction of anesthesia, rocuronium (0.6 mg / kg) was rapidly infused into the forearm vein of the child. Muscle relaxation monitor was used to detect the degree of muscle relaxation after injection. The onset time, recovery time, recovery, and hemoglobin and hematocrit of rocuronium in the three groups were recorded. Results The onset of rocuronium in children with cyanotic congenital heart disease was significantly longer than that in non-cyanotic congenital heart disease group and the control group (P <0.05). Cyanotic congenital heart disease Children hemoglobin levels, hematocrit were significantly higher than non-cyanotic congenital heart disease group and control group, the difference was statistically significant (P <0.05). Conclusion The use of rocuronium in children with cyanotic congenital heart disease has a long onset and low sensitivity. It is necessary to carry out individualized muscle relaxation monitoring program in children with cyanotic congenital heart disease.