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体外实验中观察了本院合成的安吖啶对3株肿瘤细胞的抗癌作用.结果表明,安吖啶对L_(1210)细胞及2株人肿瘤细胞HEP及HCE均具有较强的抗癌效果.对L_(1210)细胞的杀伤效果最强,杀死1或2个log(即杀死90%和99%)瘤细胞的浓度依次为0.08及0.25μg/ml,对HCE和HEP细胞杀死1个log细胞的浓度分别为0.98及1.25μg/ml.体内实验证明本药对小鼠实体瘤S_(180)及腹水瘤L_(1210)均具有较好疗效.1～3mg/kg每天腹腔注射1次连续6天,可使荷腹水型L_(1210)瘤小鼠的活存时间较对照组延长193～214%,对S_(180)实体瘤生长的抑制率可达47～85%.与美国国立肿瘤研究所赠送的标准品NSC-249992作了比较,证明二者的抗癌效价相似.
The anticancer effect of amsacrine on three tumor cells in vitro was observed in vitro.Results showed that amsacrine had strong anticancer effect on both H12 and HCE cells in L1210 cells and in two human tumor cells The strongest killing effect on L 1210 cells was that the killing of 1 or 2 log (ie 90% and 99% killing of tumor cells) was 0.08 and 0.25 μg / ml, respectively, killing HCE and HEP cells The concentration of dead 1 log cell was 0.98 and 1.25 μg / ml, respectively.Its in vivo experiments showed that the drug had a good effect on S 180 and ascites tumor L 1210 in mice, and 1-3 mg / kg per day One injection of 6 consecutive days could prolong the survival time of mice bearing L1210 tumor by 193-214% compared with the control group and 47-85% inhibition of the growth of S 180 solid tumor. Compared with the standard NSC-249992 donated by the National Institute of Cancer, the anti-cancer potency of the two drugs is similar.