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为了研究食管测压技术对贲门失弛缓症患者药物治疗效果的监测作用 ,指导临床用药。方法 :采用食管测压技术观察了硝苯吡啶和硝酸山梨醇酯对贲门失弛缓症患者食管运动功能的影响。结果 :硝苯吡啶和硝酸山梨醇酯都可降低贲门失弛缓症患者食管下段括约肌压力 (LESP)、食管下段括约肌 (LES)残余压和食管体压力 (EBP) ,但硝酸山梨醇酯对LESP的降低作用显著强于硝苯吡啶 (P <0 .0 1～ 0 .0 0 1) ,对LES残余压和食管体压力的影响两药无显著差异 (P >0 .0 5 )。结论 :钙离子拮抗剂和硝酸酯类药物对贲门失弛缓症患者的食管运动功能的影响有一定的差异 ,通过食管测压 ,有针对性地用药 ,对于提高药物治疗效果 ,减少副反应有一定的指导意义
In order to study the esophageal manometry technique in the treatment of achalasia in patients with drug monitoring effect of the role of clinical guidance. Methods: The effects of nifedipine and sorbitol nitrate on esophageal motility in patients with achalasia were observed by esophageal manometry technique. RESULTS: Both nifedipine and sorbitol nitrate could reduce the lower esophageal sphincter pressure (LESP), the lower esophageal sphincter (LES) residual pressure and the esophageal pressure (EBP) in patients with achalasia, but the effect of sorbitol nitrate on LESP (P <0.01 ~ 0.010). There was no significant difference between the two drugs on LES residual pressure and esophageal pressure (P> 0.05). Conclusion: The effect of calcium antagonists and nitrates on esophageal motility in patients with achalasia is somewhat different. Through esophageal manometry, the targeted drugs are used to improve the therapeutic effect of drugs and reduce the side effects The guiding significance