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目的探讨克拉霉素联合阴道局部应用强力霉素治疗非淋菌性宫颈炎疗效。方法选取2013年4月~2015年5月我院妇科门诊就诊的非淋菌性宫颈炎女性患者1183例,按不同药物治疗方案分为观察A组(403例)与观察组B组(380例)和对照组(400例)。观察A组患者采用克拉霉素联合阴道局部应用强力霉素治疗,观察B组患者采用阿奇霉素联合阴道局部应用强力霉素治疗;对照组采用多西环素片口服治疗。观察三组患者临床疗效及不良反应发生情况。结果观察组A组、B组总有效率均显著高于对照组,组间差异P<0.05。观察组A组、B组总有效率比较,差异显著(P<0.05),A组疗效显著优于B组。结论非淋菌性宫颈炎采用克拉霉素联合强力霉素(阴道局部用药)治疗方案疗效可靠,不良反应较少,应推广该治疗方案。
Objective To investigate the effect of clarithromycin combined with topical vaginal administration of doxycycline in the treatment of non-gonococcal cervicitis. Methods From January 2013 to May 2015, 1183 women with non-gonococcal cervicitis treated in our gynecology clinic were divided into observation group A (403 cases) and observation group B group (380 cases) according to different drug treatment regimens, And control group (400 cases). Observation group A patients with clarithromycin combined vaginal application of doxycycline treatment, the observation group B patients with azithromycin combined with vaginal topical doxycycline treatment; the control group was treated with doxycycline tablets. The clinical efficacy and adverse reactions of the three groups were observed. Results The total effective rate of observation group A and B were significantly higher than that of the control group, P <0.05. The total effective rate in observation group A and B was significantly different (P <0.05), and the effect in A group was better than that in B group. Conclusion Non-gonococcal cervicitis with clarithromycin combined with doxycycline (vaginal topical) treatment is reliable, less adverse reactions, the treatment should be promoted.