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目的 :探讨增殖细胞核抗原 (PCNA)在肺鳞状细胞癌 (简称 )组织中的表达及其与预后的关系。方法 :5 1例手术切除的肺鳞癌组织 ,采用免疫组化 (SP)法检测 PCNA在不同临床分期及分化程度癌组织中的表达 ,应用 t检验、方差分析 (F检验 )比较其差异 ;采用 Spearm an等级相关分析其相关性。生存率分析采用 Kaplan- Meir曲线 ,L ong- Rank test检验生存期的差异。结果 :PCNA表达在不同的临床分期及分化程度间差异均显著 (P<0 .0 5 )。 PCNA和临床分期及分化程度与生存期均呈正相关 ,PCNA指数 >5 0 %组生存期明显短于 PCNA指数 <5 0%组 (P<0 .0 1)。结论 :PCNA在一定程度上可以作为肺鳞癌评价预后的指标。
Objective: To investigate the expression of proliferating cell nuclear antigen (PCNA) in lung squamous cell carcinoma (abbr.) and its relationship with prognosis. Methods: 51 cases of lung squamous cell carcinoma were resected. The expression of PCNA was detected by immunohistochemistry (SP) in different clinical stages and differentiating degree. The differences were analyzed by t test and variance analysis (F test). Spearm an level correlative analysis of its relevance. Survival analysis was performed using Kaplan-Meir curves and the L ong- Rank test was used to test for differences in survival. Results: There were significant differences in PCNA expression between different clinical stages and differentiation degrees (P < 0.05). There was a positive correlation between PCNA and clinical stage, differentiation degree and survival time. The survival period of PCNA index >50% group was significantly shorter than that of PCNA index <50% group (P<0. 01). Conclusion : PCNA can be used as an index to evaluate the prognosis of lung squamous cell carcinoma to some extent.