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目的:探讨左炔诺孕酮宫内缓释系统在围绝经期功能失调性子宫出血中的应用价值。方法:2008年1月～2010年10月来该院妇科门诊就诊的围绝经期功血患者31例,于月经来潮的第3～7天由专人放置左炔诺孕酮宫内缓释系统,并对患者治疗前后月经量、血红蛋白含量、子宫内膜厚度改善情况进行对比分析。结果:与治疗前相比,患者置入左炔诺孕酮宫内缓释系统后3、6、12个月的月经量、血红蛋白含量、子宫内膜厚度均显著改善,差别均具有统计学意义(P<0.05)。其月经量分别下降60%、73%和89%;血红蛋白水平上升,由治疗前的(98.73±6.77)g/L上升到(123.47±9.02)g/L;子宫内膜厚度明显降低,由治疗前的(13.95±4.23)mm下降到(6.10±1.21)mm。结论:左炔诺孕酮宫内缓释系统对于围绝经期功能失调性子宫出血患者的治疗具有极其重要的临床价值。
Objective: To investigate the value of levonorgestrel-releasing intrauterine system in dysfunctional uterine bleeding in perimenopausal period. Methods: From January 2008 to October 2010, 31 cases of peri-menopausal dysfunctional uterine bleeding were treated in the gynecology outpatient department of the hospital from January 2008 to October 2010. The levonorgestrel-releasing intrauterine system was placed by hand on days 3 to 7 of menstruation, And before and after treatment of patients with menstrual flow, hemoglobin content, endometrial thickness to improve the situation were analyzed. Results: Compared with those before treatment, the menstrual volume, hemoglobin content and endometrial thickness were significantly improved at 3, 6 and 12 months after levonorgestrel-releasing intrauterine system, the differences were statistically significant (P <0.05). The menstrual flow decreased by 60%, 73% and 89% respectively. The hemoglobin level increased from (98.73 ± 6.77) g / L to (123.47 ± 9.02) g / L before treatment, and the endometrial thickness was significantly decreased. The former (13.95 ± 4.23) mm decreased to (6.10 ± 1.21) mm. Conclusion: The levonorgestrel-releasing intrauterine system has an extremely important clinical value for the treatment of patients with dysfunctional uterine bleeding in perimenopausal period.