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下丘脑的黄体生成素释放激素(LRH)刺激LH和FSH的分泌。在尿中已测出存在一免疫反应的LRH样物质,层析特性类似于LRH第2位到第10位的九肽断片。为了进一步弄清在生长和性成熟过程中LRH产生的变化,作者使用一特异的LRH抗血清测定了青春发育期前以及青春发育期儿童尿提取物中的免疫反应LRH样物质的含量,同时测定了24小时尿中促性腺激素的水平,并分析了这些资料与年龄及骨龄的关系。受试者包括24例青春发育期前的男孩(4～13.9岁),12例青春发育期男孩(11～18岁),19例青春发育期前的女孩(0.25～12岁),13例青春期女孩(8～18岁)其下丘脑-垂体性腺机能正常,
The hypothalamic luteinizing hormone releasing hormone (LRH) stimulates LH and FSH secretion. An LRR-like substance with an immune response has been detected in urine and has chromatographic properties similar to that of the peptide sequence of the second to tenth of LRH. In order to further understand the changes of LRH produced during growth and sexual maturation, the authors used a specific LRH antiserum to measure the amount of LRH-like substance in the urine of pre-puberty and adolescent urinary extracts 24-hour urinary gonadotropin levels, and analyzed the relationship between these data and age and bone age. Subjects included 24 pre-puberty boys (4-13.9 years), 12 pubertal boys (11-18 years), 19 pre-puberty girls (0.25-12 years) and 13 puberty Girls (8 to 18 years old) of the hypothalamus - pituitary gland function normal,