【摘 要】
：
Therapeutic antibodies represent one of the most significant advances in the history of medicine. Progress in the antibody therapy field was initially slow and
【机 构】
：
The Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Te
论文部分内容阅读
Therapeutic antibodies represent one of the most significant advances in the history of medicine. Progress in the antibody therapy field was initially slow and intermittent. The first therapeutic antibody, murine-derived Murononab OKT3 for acute organ rejection, was approved by the FDA in 1986, more than a decade after the discovery of the hybridoma technology by Milstein and K(o)hler in 1975 (Kohler and Milstein, 1975; Emmons and Hunsicker, 1987). As a result of technological breakthroughs starting in the 1980s, progress in therapeutic antibodies accelerated dramatically. During the last 30 years, antibodies have become a major drug modality for cancer, autoimmune, infectious, cardiovascular, neurological, and other diseases. The rapid rise of antibody-based therapies is largely due to their desirable safety profile, target specificity, and efficacy. As a practitioner in the field and like many others, I have stopped from time to time to take the pulse of the therapeutic antibody landscape (An, 2009, 2010). This special issue provides readers with a snapshot of the current state of therapeutic antibodies.
其他文献
Traditional botany in ancient China mainly included agriculture and medicine.In contrast,botany in the broader mode sense was introduced from the West and estab
On March 9th,1981,Mr.Xitao Cai (Hse-Tao Tsai) (Fig.1) one of the most famous pioneer botanists in China,passed away at his age of 70 in Kunming.It has been 37 y
县医院是我国省、市、县三级医疗卫生体系的基础,又是农村三级医疗卫生服务网的龙头,是与广大农村地区群众关系最为密切的公立医院,在我国医疗服务体系中起着承上启下的重要
Early years Professor Ke Hsin Kuo was bo in Beijing in 1923,and his childhood was spent in Harbin in northeaste China where his father worked as an engineer to
The microbiologist Jilun Lis excellent work on microbial secondary metabolites and biological nitrogen fixation has made significant contributions to agricultur
请下载后查看，本文暂不支持在线获取查看简介。
Please download to view, this article does not support online access to view profile.
Shuchün Teng (or Shu-Chun Teng,1902-1970,Fig.1),courtesy name Zimu (子牧),was one of the most famous Chinese mycologists.His main achievements were in fungal t
In November 2005,scientists gathered at Times Square in New York City announced the exciting news of the successful development of the worlds first cervical can