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用放射免疫液相竞争法测定４０例不同程度充血性心力衰竭（ＣＨＦ）患儿血清中的肿瘤坏死因子α（ＴＮＦα），其中２７例经治疗好转后再次测定，并以３０例正常儿童为对照。结果：患儿的心功能越差，血清ＴＮＦα水平增高越明显；严重ＣＨＦ患儿血清ＴＮＦα水平较正常儿童显著升高，治疗好转后明显下降，但仍高于正常儿童；不同病因所致ＣＨＦ之间血清ＴＮＦα水平无统计学差异。提示：ＴＮＦα是参与ＣＨＦ发生发展的重要因素之一；血清ＴＮＦα水平可能是ＣＨＦ患者心功能程度判定和疗效观察的一项重要检测指标。
Tumor necrosis factor α (TNFα) in serum of 40 children with congestive heart failure (CHF) of varying degrees was determined by radioimmunoassay. Twenty-seven of them were measured again after treatment improved. Thirty normal children As a control. Results: The worse heart function in children, serum TNF α levels increased significantly; severe CHF serum TNF α levels were significantly higher than normal children, treatment improved significantly decreased, but still higher than normal children; different causes CHF caused by serum TNF @ levels no significant difference. Tip: TNF @ is involved in the development and development of CHF one of the important factors; serum TNF @ level may be CHF in patients with heart function to determine the extent and efficacy of an important test indicators.